In 1974, Glenville Sanatorium was the site of a brutal and horrific crime, as three hideously deformed cannibals went on a merciless killing spree. Now, years later, a group of college kids having the time of their life make a fateful wrong turn, giving this family of blood-thirsty cannibals new prey to stalk. The abandoned medical wards within the sanatorium soon become killing fields as the panicked victims come face to face with a chilling choice: fight back or die.